Temple Researchers Successfully Remove HIV-1 from Cultured Human Cells


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Researchers from the Center for Neurovirology and Comprehensive NeuroAIDS Center at Temple University have become the first to successfully remove HIV from cultured human cells. An article summarizing their work was published earlier this month by the Proceedings of the National Academy of Sciences (Proc Natl Acad Sci USA. 2014 Jul 21. [Epub ahead of print]; PMID: 25049410).

In a statement released by the university, one of the authors, Kamel Khalili, PhD, who is also professor and chair of the Department of Neuroscience and director of both the Center for Neurovirology and Comprehensive NeuroAIDS Center at Temple, noted, "This is one important step on the path toward a permanent cure for AIDS. It's an exciting discovery, but it's not yet ready to go into the clinic. It's a proof of concept that we're moving in the right direction."
 
In this National Institutes of Health-funded project, the Temple team created molecular tools designed to delete HIV-1 proviral DNA. When deployed, a combination of a DNA-snipping nuclease and a targeting strand of RNA (guide RNA, or gRNA) effectively hunt down the viral genome and excise the HIV-1 DNA, according to their findings. From there, the cell's gene repair machinery takes over, connecting the loose ends of the genome to create virus-free cells. The research shows that these molecular tools also hold promise as a therapeutic vaccine; cells armed with the nuclease-RNA combination proved impervious to HIV infection.

 

 

http://www.inflexwetrust.com/2014/07/28/have-you-heard-temple-university-researchers-eliminate-hiv-virus-from-human-cells/

 

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hmm. Sounds promising. maybe trying to find a medical cure will be surpassed by this... Freak, by all means keep us posted if you have the time...

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Temple University is around the corner from where I live. It sounds fantastic that they did this but as far as a hospital, it is one of the worst in quality and customer services in Philadelphia.

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