No plugins - intial load = 8 seconds, subsequent loads = 3 seconds.
Resharper installed - initial = 18 seconds, subsequent = 9 seconds.
The VMWare Virtual Debugger Visual Studio 2010 plugin really kills it for me, that buggy plugin takes my Visual Studio 2010 start-up times to 60-80 seconds.
I do that quite often, never had any delays.
have you ever opened a web.config file directly in VS2010 or VS2008 just to do a quick edit? external to the solution you are in, just like right click web.config open in VS?... we always have this odd delay, it takes about 1 minute to open the file like it has to think about what to do, after that opens fine and saves fine.... every one of our dev machines repos this... always been an odd behavior, and MS always closes our bugs on it as "by design"