Nuclear decontamination pill "highly effective"

[DocM]

Link....

Nuke decontamination pill "highly effective"

Rapid, mass decontamination following a nuclear reactor accident or terrorist "dirty bomb" attack may be in the offing with Berkeley Lab researchers reporting they have begun seeking FDA approval for trials of an orally administered decontamination agent.

The process of decontaminating the body of radioactive particles hasn't advanced much in half a century, with only one chemical agent available. That compound, known as DTPA**, is widely regarded as a relic from the Cold War and is only partially effective at removing radioactive elements from the body.

The lack of research in the area is somewhat surprising given that Japanese officials considered the evacuation of more than 30 million Tokyo residents following last year's triple meltdown at the Fukushima nuclear reactor.

Now, however, Berkeley Lab scientists say they have developed a much more effective treatment that decontaminates a large number of the elements (known as actinides) that are likely to be part of the radiation exposure from a nuclear plant or weapon, including plutonium, americium, curium, uranium and neptunium.

Depending on the level of radiation exposure and how soon treatment can start, the researchers claim one of these pills would result in the excretion of approximately 90-percent of the actinide contaminants within 24 hours. Taking one pill daily for two weeks should, they believe, be enough to remove virtually all of the actinide contaminants.

"With the expanding use of nuclear power and unfortunate possibility of nuclear weapon use, there is an urgent need to develop and implement an improved therapy for actinide contamination of a large population," says Berkeley Lab scientist Rebecca Abergel. "We are now in the process of demonstrating that our actinide-specific decontaminating agents are ready for clinical development."

Abergel and her group are part of an effort at Berkeley Lab to identify agents that can encapsulate actinides into tightly bound cage-like chemical complexes for transport out of the body. The early focus of this research was on plutonium and natural chelators (crablike molecules that specifically bind with iron and other metal ions).

"Since the biochemical properties of plutonium and iron are similar, we modeled our sequestering agents after the chelating unit found in siderophores," explained the research leader Ken Raymond. Siderophores are small molecules secreted by bacteria to extract and solubilize iron.

The technique of copying Mother Nature appears to have paid dividends, with Raymond claiming the sequestering agents (known as hydroxypyridonate ligands, or HOPOs) his team have created are unrivaled in terms of actinide-affinity, selectivity and efficiency.

The two best candidate HOPOs developed by the team are a tetradentate, which has four chelating arms, and an octadentate (pictured), which has eight chelating arms. The "arms" in this case are atoms with pairs of electrons available for covalent bonding with an actinide.

Each variant has its own merits, explains Abergel. "A single octadentate HOPO can form a full actinide complex and results in more total actinide excretion. However, it is easier for the smaller tetradentate HOPO to pass through biological membranes and access desired target sites in the body. Both warrant further development for emergency use in the case of a radiological event."

Abergel says the team have carried out extensive experiments in animal models and human cell lines that have established the two HOPO candidates as being highly effective and non-toxic at the tested doses. She and her group have now started the process with the FDA to determine what further data is needed to move into clinical trials.

** Diethylene triamine pentaacetic acid -?mainly used for sequestering metal ions that otherwise decompose hydrogen peroxide.

[+Mirumir Subscriber¹]

This is really cool! Let's hope one day there will be a pill which can make us completely immune to radioactive energy (or make the whole process reversible) thereby making nuclear weapons obsolete (we just gonna need space suits like those of the marines from SC2 :rofl: to shield from a blast).

Depending on the level of radiation exposure and how soon treatment can start, the researchers claim one of these pills would result in the excretion of approximately 90-percent of the actinide contaminants within 24 hours.

I get this part. But what exactly are these actinide contaminants? How do they fit in the whole radioactive decay process?

[Jub]

I wish they had these when George Mason was exposed.

[DocM]

I get this part. But what exactly are these actinide contaminants? How do they fit in the whole radioactive decay process?

The actinides start at atomic number 89 and are named for Actinium, the first in the serirs. All have numerous radioactive isotopes and thus are high up the contamination ladder. Tough nuts they are.

List:

Actinium,?Thorium,?Protactinium,?Uranium,?Neptunium,?Plutonium,?Americium,?Curium,?Berkelium,?Californium,?Einsteinium,?Fermium,?Mendelevium,?Nobelium and?Lawrencium.

[Astra.Xtreme]

This is really cool! Let's hope one day there will be a pill which can make us completely immune to radioactive energy (or make the whole process reversible) thereby making nuclear weapons obsolete (we just gonna need space suits like those of the marines from SC2 :rofl: to shield from a blast).

Haha, well I don't think it would make nuclear weapons obsolete. That pill would have to shield from vaporization too. :rofl:

It would protect us better from dirty bombs and nuclear fallout.

[DocM]

And under testing is s treatment for acute radiation syndrome - radiation poisoning. Some medical lab rats at Harvard and Rand got the idea that a mix of the antibiotic Cipro and a synthesized human immune protein named rBPI21 might be useful if started soon after exposure..

To test it they exposed mice (a good human analog) to 7 Gy of radiation (a chest x-ray is 0.01 Gy), which has a. 90% mortality at 30 days.

Instead of 90% dying at 30 days 80% of the furry ones were still alive, their blood counts had rebounded and they were scurrying about doung their mouse thing.

Both are well tolerated in humans, and the last I heard they were looking to test them on radiation therapy patients.

[BoredBozirini]

Plant these pills in Pripyat to see if they fix the problem faster.