No it wouldnt, not every time, you're assuming to much. What you can assume is in order for their to be sounds, there has to be movement. Only a few things move inside a computer, fans, HDD, and optical drives. If it was clicking, and you replaced/moved a couple things, it is more likely that they were rubbing against a fan.
Before you go thinking "click is gone, no more problems" run HDTune's error check.
Oh, and there is no such thing as a 4-pin SATA molex, at least any more. Its one or the other.
Erm no, there was nothing rubbing against a fan and the clicking was the drive (more on that in a minute), the clicking was louder than a hdd/optical drive read write cycle and deffinately not a fan clicking.
Oh and there is such a thing as 4-pin SATA molex, in case your unsure these are SATA cables with either one or two SATA power connectors with a 4-pin male molex connector that connects to a 4-pin female connector from the PSU.
So down to the drive itself, yes it did fail or on the verge or failing, today it was preventing my PC from booting, during post a message appeared stating that Slave 3 had failed.
So checking the Main Tab in the bios, next to Third IDE Slave, instead of showing my HDD model number it instead had "J9J9J9J9J9J9J9" and a random capacity amount, so i quickly transfered the data to another drive, removed the affected HDD and Completed an RMA. The HDD is a Seagate Barracuda 7200.11 1TB that i have had for 4 years, luckily its under warranty until August 28 2013.
But i have to say i'm a little worried about hooking it back up to mu computer to run SeaTools or HDD Regenerator 2011.