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Grapefruit juice boosts drug's anti-cancer effects

university of chicago medicine sirolimus

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#1 Hum

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Posted 08 August 2012 - 00:19

Sirolimus, a drug typically used by transplant patients to prevent rejection, has been found in previous studies to have anti-cancer properties as well. While it’s not currently used to treat cancer, there may be a way to give those properties a boost, and make the drug a feasible option for cancer patients – by adding some grapefruit juice.

A new study from the University of Chicago Medicine revealed patients taking sirolimus receive more of its anti-cancer benefits if they drink a glass of grapefruit juice every day along with the drug. The drug-juice combination was so effective that patients who drank grapefruit juice obtained three times as many benefits than those who took the drug alone.

This is also interesting because of grapefruits’ dangerous interaction with some prescription medications, namely ones that treat high blood pressure and heart conditions.

Researchers had discovered sirolimus’ potential anti-cancer properties from previous research.

“It’s a drug that was discovered in the 70s,” Dr. Ezra Cohen, a cancer specialist at the University of Chicago Medicine and the study’s lead author, told FoxNews.com. “It was clearly shown to have anti-cancer effects and anti-neoplastic effects, but it hadn’t been developed for cancer extensively because the patent ran out. There wasn’t a lot of commercial interest to develop sirolimus, so it sort of was pushed aside for a while. Eventually, sirolimus was indeed approved, but for people who got organ transplants to prevent rejection.”

Cohen and his team study how food consumption can either help or hurt the effectiveness of drugs used for cancer therapy.

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#2 DocM

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Posted 08 August 2012 - 01:15

That grapefruit can increase the activity of some frugs is old news.

#3 OP Hum

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Posted 08 August 2012 - 22:30

^ Not for everybody on Neowin.

more:

http://www.foxnews.c...cer-properties/

#4 HighwayGlider

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Posted 25 September 2012 - 08:36

But that thing's so bitter.

#5 DocM

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Posted 25 September 2012 - 13:16

A lot of people like that bitter-y flavor. Count me as one.

#6 Yazoo

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Posted 25 September 2012 - 13:36

add some rum and sugar syrup to a glass of grapefruit juice, after the first couple of glasses you forget the bitterness ;)

#7 OP Hum

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Posted 25 September 2012 - 14:06

I'd mix grapefruit with some orange juice :p

#8 Big b0b

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Posted 25 September 2012 - 14:08

Why would they approve a patent on a drug that got rid of cancer that makes the pharmicutial companies so rich?

#9 OP Hum

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Posted 25 September 2012 - 14:12

^ The company spent millions on Research and are entitled to make a profit.

#10 Slammers

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Posted 25 September 2012 - 14:16

Yup, grapefruit messes with many drugs, makes them kick in faster etc.
That's why people mix it with cough medicine to get truly ****ed up :D

#11 Big b0b

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Posted 25 September 2012 - 15:06

Yup, grapefruit messes with many drugs, makes them kick in faster etc.
That's why people mix it with cough medicine to get truly ****ed up :D


never knew that, hahahah

#12 Growled

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Posted 26 September 2012 - 03:07

A lot of people like that bitter-y flavor. Count me as one.


I'm not one. I hate the taste but I'd drink it if helped cure me.