The problem I have with them making another Mass Effect (other than the obvious: they butchered the end of ME3 and ruined the entire series) is continuing the universe based on your choices from the last game. Every ending in ME3 fundamentally changed the ME universe to the point that any sequal (direct or set long after the events of ME) won't be able to follow all three endings well enough.
For instance, if you took the synthesis ending, all life in the universe is now part organic and part synthetic. That opens the door for HUGE story-telling and plot differences versus, say, the ending where you just destroy the reapers. The back-stories, interactions between characters/species, technology, driving forces are all entirely different; and so the resulting story would be (should be) entirely different. Including continuations for all of the ME3 endings isn't as simple as connecting ME1 to ME2, or 2 to 3. The rules are completely different in each ending. It's not practical, from EA's standpoint, to develop three wholly-different stories.
So, as I see it EA can do one of four things. 1 - develop a prequel series that takes place before ME1 (lame, who cares?). 2 - develop a new series that takes place during the same time period as ME1-3. (again lame, we already have the multiplayer for something like that, and who cares about characters that aren't central to Shepard's plot?) 3 - develop three entirely different universes, and therefore entirely different stories, characters, and mechanics based each ending of the three endings from ME3. (impractical, not fiscally sound for EA; so it won't happen) 4 - pick a "canon" ending and go with that for the aftermath of ME3 (lame. renders the story of every player who played the originals and didn't pick that option moot)
I'm all for more Mass Effect, assuming they can keep the same level of detail and polish. But, I just don't see any good way of building off of ME3 in any meaningful way.
This. The gameplay is pretty damn derivative.
Also, calling this game/series an RPG is a bit of a stretch too.
Mass Effect is every bit an RPG as any other game you can name. In fact, it's more of an RPG than most other RPGs.