Jump to content



Photo

New drug mimics the beneficial effects of exercise

drugs effects exercise sr9009

  • Please log in to reply
12 replies to this topic

#1 Crisp

Crisp

    To infinity and beyond

  • 5,415 posts
  • Joined: 06-May 10
  • Location: 127.0.0.1

Posted 21 August 2013 - 11:23

New drug mimics the beneficial effects of exercise

scripps-drug-sr9009-exercise-mimic-2.jpg

The Scripps Research Institute has developed a drug that duplicates the benefits of exercise – at least for mice (Photo: Shutterstock)

 

A drug known as SR9009, which is currently under development at The Scripps Research Institute (TSRI), increases the level of metabolic activity in skeletal muscles of mice. Treated mice become lean, develop larger muscles and can run much longer distances simply by taking SR9009, which mimics the effects of aerobic exercise. If similar effects can be obtained in people, the reversal of obesity, metabolic syndrome, and perhaps Type-II diabetes might be the very welcome result.

 

The drug was developed by Professor Thomas Burris of TSRI, who found that it was able to reduce obesity in populations of mice. It binds to and activates a protein called Rev-ErbAα, which influences fat and sugar burning in the liver, production of fat cells, and he body's inflammatory response.

 

Source and more




#2 threetonesun

threetonesun

    Neowinian Senior

  • 11,943 posts
  • Joined: 26-February 02

Posted 21 August 2013 - 11:47

Uh huh. I'd like to see how those mice livers hold up after 80 years.



#3 FloatingFatMan

FloatingFatMan

    Resident Fat Dude

  • 15,357 posts
  • Joined: 23-August 04
  • Location: UK

Posted 21 August 2013 - 12:02

Uh huh. I'd like to see how those mice livers hold up after 80 years.

 

So would I... An 80 year old mouse would be a massive breakthrough in the search for immortality! :p



#4 threetonesun

threetonesun

    Neowinian Senior

  • 11,943 posts
  • Joined: 26-February 02

Posted 21 August 2013 - 12:28

So would I... An 80 year old mouse would be a massive breakthrough in the search for immortality! :p

 

They're working on it: http://www.cbsnews.c...6-10391704.html

 

i just think it's funny when another study comes out which says, "look what we can do to mice!" as though it's just a minor tweak to get it working in humans.



#5 FloatingFatMan

FloatingFatMan

    Resident Fat Dude

  • 15,357 posts
  • Joined: 23-August 04
  • Location: UK

Posted 21 August 2013 - 12:29

They're working on it: http://www.cbsnews.c...6-10391704.html

 

i just think it's funny when another study comes out which says, "look what we can do to mice!" as though it's just a minor tweak to get it working in humans.

 

For a lot of things, it IS just a minor tweak. That's why they use mice.



#6 threetonesun

threetonesun

    Neowinian Senior

  • 11,943 posts
  • Joined: 26-February 02

Posted 21 August 2013 - 13:21

For a lot of things, it IS just a minor tweak. That's why they use mice.

 

Not quite true. It's very easy to genetically alter mice, and they are genetically similar to humans, so it's easy to say, give a thousand mice a cancer which affects humans and run tests on them. Getting that research into humans is a very different, very large, gap.

 

It's very easy to do a lot of wacky things to mice, or other small mammals (see the glow in the dark rabbits from last week, or any mice which have been genetically altered to be flawed), but going from that to human testing to full on human production is an entirely different story.



#7 Growled

Growled

    Neowinian Senior

  • 41,508 posts
  • Joined: 17-December 08
  • Location: USA

Posted 21 August 2013 - 16:21

Uh huh. I'd like to see how those mice livers hold up after 80 years.

They will probably need another pill for that. ;)



#8 airedwin

airedwin

    Neowinian

  • 167 posts
  • Joined: 27-November 12

Posted 21 August 2013 - 18:17

So would I... An 80 year old mouse would be a massive breakthrough in the search for immortality! :p

ya, soon mice will be immortal and the rulers of the planet



#9 AR556

AR556

    Neowinian Senior

  • 5,604 posts
  • Joined: 07-August 03

Posted 29 October 2013 - 11:28

Ah...the wonders of Mice medicine and graphene......



#10 psionicinversion

psionicinversion

    Neowinian Senior

  • 1,859 posts
  • Joined: 16-June 05

Posted 29 October 2013 - 11:35

Thats amazing, a new way of people thinking they can get away with not excercising.... its pathetic. So people will think they can just sit on the arses take a tablet and think theyve done a 6 mile run. 1 of the things excercise does is change your mood cus your out of the house breathing in fresh air etc. i know this tablet alongside anti-depressants, = total win obviously



#11 Hum

Hum

    totally wAcKed

  • 61,981 posts
  • Joined: 05-October 03
  • Location: Odder Space
  • OS: Windows XP, 7

Posted 29 October 2013 - 22:06

Now put the drug in our chocolate bars ! :p



#12 Garnet H.

Garnet H.

    astropheed

  • 1,617 posts
  • Joined: 08-December 11
  • Location: Sydney, AU

Posted 29 October 2013 - 22:14

So if I take this drug and exercise does my Liver explode?

 

Also I'd be far more interested in the tablet that allows Mice to live to 80 :) This whole 'dying' thing needs to get sorted.



#13 bradsday

bradsday

    Neowinian

  • 367 posts
  • Joined: 26-November 05
  • Location: Bangkok, Thailand (American Abroad)
  • OS: Windows 8/7/Vista/XP - OSX 10.7 Lion
  • Phone: BlackBerry 9700

Posted 15 January 2014 - 08:54

Uh huh. I'd like to see how those mice livers hold up after 80 years.

 

Me too!  Mouse liver pâté, anyone?





Click here to login or here to register to remove this ad, it's free!