Avast scores fairly low in terms of protection in comparison to others, consider switching: http://www.av-test.o...-8/novdec-2013/
You can probably ditch "spyware bot" and adaware.
Are you using malwarebytes free or pro? Pro allows it to run constantly in the background alongside your AV (which it's designed to do, despite what some others may misguidedly try to tell you), and is pretty cheap considering it is a one off lifetime license, including free upgrades to new versions. Consider paying for pro if you haven't already.
Make sure you install updates to your OS/apps/plugins promptly. Make sure you're using a non-admin Windows user account for day-to-day stuff, keeping an admin account just for maintenance tasks that require it.
If you're still using Windows XP, get yourself upgraded pronto, as of 8th April you'll no longer be getting any security updates.