I recently upgraded from two 6970 to two 280X. The other day I hooked up my 2nd monitor back up. Now everything I play a game and exit back to the desktop my main monitor screen goes crazy like it has the wrong refresh rate. I get a bunch of flickering, noise lines, and what not. I end up having to reboot. I'm running 14.6RC drivers and once I remove the 2nd monitor everything works fine. I'm running the monitors as extended desktop. One monitor is hook up via DVI and the other HDMI. Both monitors are running at 1920 x 1080 with 60Hz refresh rate.