JohnsonBox Posted April 18, 2013 Share Posted April 18, 2013 I think you guys may not need to read the recent collegepoisoning case in China. But if you're interested, click: China's Prestigious Univ's Student Poisoning Death Case Serves as a Reminder (Police examined the water left in the water dispenser in the dormroom and found poisonous chemicals) Another case: Zhu Ling Poisoning Case (the first case that stirred WWW) Here let's discuss how to prevent poisoning. A traditional method is use silver chopsticks or poons to detect possible poisons in food or drink. But such method has its obvious limits: Only inorganic poisons like potassium cyanide or arsenic can be discovered, while organic poisons like Fussol. Emporers of China ordered his eunuchs to taste the food first and today's some people might use animals to try it out (will WSPA protest?). But what do you do? Link to comment Share on other sites More sharing options...
gameboy1977 Posted April 18, 2013 Share Posted April 18, 2013 opps wrong post.... Link to comment Share on other sites More sharing options...
JohnsonBox Posted April 21, 2013 Author Share Posted April 21, 2013 Toxicity Testing in the 21st Century: Bringing the Vision to Life Abstract In 2007, the U.S. National Academy of Sciences released a report, Toxicity Testing in the 21st Century: A Vision and a Strategy, that envisions a not-so-distant future in which virtually all routine toxicity testing would be conducted in human cells or cell lines in vitro by evaluating cellular responses in a suite of toxicity pathway assays using high-throughput tests, that could be implemented with robotic assistance. Risk assessment based on results of these types of tests would shift towards the avoidance of significant perturbations of these pathways in exposed human populations. Dose-response modeling of perturbations of pathway function would be organized around computational systems biology models of the circuitry underlying each toxicity pathway. In vitro to in vivo extrapolations would rely on pharmacokinetic models to predict human blood and tissue concentrations under specific exposure conditions. All of the scientific tools needed to affect these changes in toxicity testing practices are either currently available or in an advanced state of development. A broad scientific discussion of this new vision for the future of toxicity testing is needed to motivate a departure from the traditional high dose animal-based toxicological tests, with its attendant challenges for dose and species extrapolation, towards a new approach more firmly grounded in human biology. The present paper, and invited commentaries on the report that will appear in Toxicological Sciences over the next year, are intended to initiate a dialog to identify challenges in implementing the vision and address obstacles to change. Link to comment Share on other sites More sharing options...
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