My '91 lasted until '09 but only had about 150K on it. It had a slight oil leak and one day the transmission just crapped itself (Might have been my fault, I didn't keep up with the fluids it needed often enough). The rest of the engine still ran great though. My friends have seen it driving around town since I sold it, so I guess someone put a new tranny in it and got it running again no problem.
my dad had a 94' s10 with a 2.2L that went to about 270k before he got rid of it. He replaced the head gasket once, had to get the tranny rebuilt twice. He only changed the oil every 6k miles. It still ran just fine when he got rid of it, he just wanted something better for the winter, it was two wheel drive.