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Drug helps mice lose weight without diet, exercise

amlexanox university of michigan anti-obesity

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#1 Hum

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Posted 11 February 2013 - 00:18

(CNN) -- A relatively obscure drug used to treat mouth sores has made obese mice thin -- and the mice didn't have to eat less or exercise more, according to a study at the University of Michigan.

Doctors at the university will begin studies in human beings later this year. Hopes are high, even though many drugs that work in mice do not work in humans.

"It is a tour de force and offers a new and potentially exciting opening for developments of new anti-obesity drugs -- something which is badly needed," says Dr. George Bray, chief of the Division of Clinical Obesity and Metabolism at Pennington Biomedical Research Center at Louisiana State University.

In the study at the University of Michigan, researchers gave mice a high-fat diet, and they became obese. They then injected the animals with a drug called amlexanox, which has been on the market for more than 15 years to treat canker sores. The mice lost weight, even though they kept eating the same number of calories. When they were taken off the drug, the mice gained all the weight back.

"It could well be that what works for one disease will turn out to work for another, even though that wasn't the original intent," he said.

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#2 1941

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Posted 11 February 2013 - 00:36

Good, I can buy smaller traps now.

#3 Original Poster

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Posted 11 February 2013 - 00:41

remember people gets rid of weight not cholesterol

#4 theyarecomingforyou

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Posted 11 February 2013 - 00:55

In the study at the University of Michigan, researchers gave mice a high-fat diet, and they became obese. They then injected the animals with a drug called amlexanox, which has been on the market for more than 15 years to treat canker sores. The mice lost weight, even though they kept eating the same number of calories. When they were taken off the drug, the mice gained all the weight back.


Sounds like they need to start adding it to Big Macs and Coca Cola then.

#5 OP Hum

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Posted 11 February 2013 - 01:02

A fat mouse is a happy mouse. :p

#6 DocM

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Posted 11 February 2013 - 01:15

It's used in parts of Asia as a treatment for asthma because of its anti-inflammatory and antiallergenic activity. Brand names are Aphthasol, Lexanox, Apsol and Solfa.

#7 Growled

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Posted 11 February 2013 - 01:40

It doesn't automatically make the user healthy though.

#8 FloatingFatMan

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Posted 14 February 2013 - 07:33

It doesn't automatically make the user healthy though.


But could potentially help the seriously obese to drop enough so that they can start to exercise properly. I've seen plenty of people that are so large that exercise would be impossible for them.

#9 Raze

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Posted 14 February 2013 - 07:45

We already have a drug for that -

Posted Image


;)

#10 Aheer.R.S.

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Posted 14 February 2013 - 07:47

Still unsure what the breeding potential of said mouse would be, or the change in mouse population just because suddenly, a few become hotter than the rest........

#11 Hardcore Til I Die

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Posted 14 February 2013 - 07:56

This will just make the lazy even lazier.

Who has the motivation for hard work? That's all I'm getting from this. :rolleyes: