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Cocaine vaccine going to human trials


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#1 DocM

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Posted 12 May 2013 - 05:54

http://i.medicalxpre...key-hurdle.html

Researchers at Weill Cornell Medical College have successfully tested their novel anti-cocaine vaccine in primates, bringing them closer to launching human clinical trials. Their study, published online by the journal Neuropsychopharmacology, used a radiological technique to demonstrate that the anti-cocaine vaccine prevented the drug from reaching the brain and producing a dopamine-induced high.

"The vaccine eats up the cocaine in the blood like a little Pac-man before it can reach the brain," says the study's lead investigator, Dr. Ronald G. Crystal, chairman of the Department of Genetic Medicine at Weill Cornell Medical College.

"We believe this strategy is a win-win for those individuals, among the estimated 1.4 million cocaine users in the United States, who are committed to breaking their addiction to the drug," he says. "Even if a person who receives the anti-cocaine vaccine falls off the wagon, cocaine will have no effect."

Dr. Crystal says he expects to begin human testing of the anti-cocaine vaccine within a year.

Cocaine, a tiny molecule drug, works to produce feelings of pleasure because it blocks the recycling of dopamine—the so-called "pleasure" neurotransmitter—in two areas of the brain, the putamen in the forebrain and the caudate nucleus in the brain's center. When dopamine accumulates at the nerve endings, "you get this massive flooding of dopamine and that is the feel good part of the cocaine high," says Dr. Crystal.

The novel vaccine Dr. Crystal and his colleagues developed combines bits of the common cold virus with a particle that mimics the structure of cocaine. When the vaccine is injected into an animal, its body "sees" the cold virus and mounts an immune response against both the virus and the cocaine impersonator that is hooked to it. "The immune system learns to see cocaine as an intruder," says Dr. Crystal. "Once immune cells are educated to regard cocaine as the enemy, it produces antibodies, from that moment on, against cocaine the moment the drug enters the body."
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#2 The_Observer

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Posted 12 May 2013 - 06:03

cool

#3 IsItPluggedIn

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Posted 12 May 2013 - 23:56

This seams like a great idea. I wonder how many of the 1.4 million are actually committed enough to use this. Most people "fall of the wagon" because they never wanted to give up in the first place.

The statistics after this will be interesting, how many of the 1.4 million take up a different drug after the cocaine no longer works.

#4 srbeen

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Posted 13 May 2013 - 00:00

Anyone who is arrested for cocaine use/trafficking should be forced to take this for a year period.

Should this work, herion and meth should also be able to be removed from the body using the same technique to inhibit their high.

And let me go out on a limb here, but if its 'eaten up' by the antibodies, then a user has NO ability to overdose from it, correct?

#5 Lizardslap

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Posted 13 May 2013 - 00:01

I wonder how this would affect people that could need codine based pain killers in the future

#6 macrosslover

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Posted 13 May 2013 - 00:02

a drug to get off a drug lol, that won't be abused at all. Joking aside the only way this works is if the people actually take it and stick to it and not willingly relapse.

#7 Growled

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Posted 13 May 2013 - 00:22

Very neat idea. I like how even if you take cocaine it has no effect after taking the anti-vaccine.

#8 theyarecomingforyou

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Posted 13 May 2013 - 00:41

Anyone who is arrested for cocaine use/trafficking should be forced to take this for a year period.


It concerns me that you think it's appropriate to force such a treatment upon somebody. Forced medical treatment violates human rights and centuries of medical practice. However, such a vaccine could be offered in exchange for reduced criminal sentences and should be offered for free to anybody addicted to cocaine. Portugal has demonstrated that decriminalisation can reduce drug usage and increase the number seeking medical treatment for addiction and that is something that other countries should seriously consider, especially the US with it's incredibly draconian and racially biased drug laws.

#9 Growled

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Posted 13 May 2013 - 00:46

Portugal has demonstrated that decriminalisation can reduce drug usage and increase the number seeking medical treatment for addiction and that is something that other countries should seriously consider, especially the US with it's incredibly draconian and racially biased drug laws.


I have never understood how that works. You would think decriminalization and having more access to drugs would bring about more drug usage.

#10 zhangm

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Posted 13 May 2013 - 00:51

This seams like a great idea. I wonder how many of the 1.4 million are actually committed enough to use this. Most people "fall of the wagon" because they never wanted to give up in the first place.

The statistics after this will be interesting, how many of the 1.4 million take up a different drug after the cocaine no longer works.


Commitment? It's a vaccine. You dose once or a couple times, and it programs the immune system to take out cocaine.

#11 n_K

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Posted 13 May 2013 - 00:52

I have never understood how that works. You would think decriminalization and having more access to drugs would bring about more drug usage.

Same thing as alcohol, 'sorry you can`t have this until you`re 21' = most under 21 year olds want it.

#12 Growled

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Posted 13 May 2013 - 00:54

Same thing as alcohol, 'sorry you can`t have this until you`re 21' = most under 21 year olds want it.


Most over 21 want it too. :D

#13 OP DocM

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Posted 13 May 2013 - 00:55

I wonder how this would affect people that could need codine based pain killers in the future


In the US cocaine is mainly been used for lacrimal duct and nasal surgery, and it's still available but not often used because of its such a strong vasoconstrictor and the risk of cardiovascular toxicity. Proparacaine, benzocaine, tetracaine, lidocaine, lignocaine, xylocaine etc. etc. are the main substitutes and they work well. IF for some reason vasoconstriction is needed diluted epinephrine can be used with them.

Kick it to the kerb.

#14 Torolol

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Posted 13 May 2013 - 01:04

decriminalization will removes the 'cool' effect & bragging right of using it,
this more rooted to human psychology than reasons,
and yes decriminalization of drugs would usually lower its price.

#15 Authentic X

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Posted 13 May 2013 - 01:10

Maybe it will get rid of crackheads?