Oritavancin: single dose treatment for MRSA

[DocM]

Where was this when I needed it? :angry:

http://m.sciencedaily.com/4.0/#!/article/94930/97593610

One and done: New antibiotic could provide single-dose option

In the battle against stubborn skin infections, including methicillin-resistant Staphylococcus aureus (MRSA), a new single-dose antibiotic is as effective as a twice-daily infusion given for up to 10 days, according to a large study led by Duke Medicine researchers.

Researchers said the advantage of the new drug, oritavancin, is its potential to curtail what has been a key driver of antibiotic resistance: a tendency for patients to stop taking antibiotics once they feel better. In such instances, the surviving bacteria may become impervious to the drugs designed to fight them.

"The prolonged activity is what makes oritavancin distinctive," said G. Ralph Corey, M.D., lead author of the study published June 5, 2014, in the New England Journal of Medicine (NEJM). "This drug has a long half-life, which allows for a single-dose treatment."

Corey, a professor of medicine and infectious diseases at Duke University School of Medicine, led a three-year study of oritavancin that encompassed two large clinical trials enrolling nearly 2,000 patients. Findings from the trials will be presented to the U.S. Food and Drug Administration as part of the drug's approval application.

Results reported in the NEJM are for the first of the two clinical trials, which included 475 patients randomized to take the investigational drug, and 479 patients following a typical regimen of vancomycin, including two infusions a day, for seven to 10 days.

Researchers found that the single intravenous dose of oritavancin was as effective as vancomycin in shrinking the size of the lesion and reducing fever. Both were also similar in rates of requiring a rescue antibiotic.

The new antibiotic also performed similarly to vancomycin in reducing the area of the wound by 20 percent or more within the first 48-72 hours of treatment, and in curing the patients of infection, including those infected with MRSA.

"Having a single-dose drug could potentially prevent hospitalizations or reduce the amount of time patients would spend in the hospital," Corey said.

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[Draconian Guppy]

you had MRSA?

 

Even though they found it, doesn't mean its widely available yet.

[mikill]

vancomicyn, from what i was told in the hospital, is more of a broad spectrum antibiotic. for MRSA they gave me a prescription for Zyvox. one pill every 12hrs for ten days.

[DocM]

you had MRSA?

Even though they found it, doesn't mean its widely available yet.

Lost my right lower leg to it. 3 surgeries in 2 days chasing it up the leg, kidney failure, 2 weeks in ICU, 4 months on IV antibiotics, 2 visits from CDC because of the 12 people who'd had that strain I was the only one alive. There's a long thread of my journey in Members Metropolis.

[123456789A]

Lost my right lower leg to it. 3 surgeries in 2 days, chasing it up the leg, kidney failure, 2 weeks in ICU, 4 months on IV antibiotics, 2 visits from CDC because of the 12 people who'd had that strain I was the only one alive. There's a long thread of my journey in Members Metropolis.

 

wtf how did that happen?

[Torolol]

single dosage are ideal for antibiotic, but in reality this rarely happens.

[DocM]

wtf how did that happen?

Being an adult onset type 1 diabetic (aka LADA) didn't help. Had a small wound on my foot that was under care, but MRSA got started and just took off.

[mikill]

Lost my right lower leg to it. 3 surgeries in 2 days chasing it up the leg, kidney failure, 2 weeks in ICU, 4 months on IV antibiotics, 2 visits from CDC because of the 12 people who'd had that strain I was the only one alive. There's a long thread of my journey in Members Metropolis.

 

wow man, thats some pretty scary stuff you've experienced. just being in the hospltal for 5 days was bad enough for me, let alone losing a critcal member of the body :(

[DocM]

Between St. Mary's and the rehab hospital (where I continued on 4 different IV antibiotics etc.) I was in for several months. Quite a ride. When I first entered the rehab I couldn't even turn on my side. Walked out on my own steam.

That side now has a very expensive limb & foot that looks like Terminator hardware. It has a Bluetooth remote control (for mode presets, vacuum pump attachment to the stump etc.), lithium ion power and moves in almost all the ways a real foot does plus it has shock absorbers. Good from 10m underwater to 6,100m altitude.