Putting in Skype support for Microsoft's Xbox console would seem to be a no-brainer. Now there's evidence that the Skype team is indeed hiring folks to work on a version of the Internet phone software service for the next generation of the Xbox hardware.
Skype is working on powering real-time voice and video communications on the Xbox. Xbox is a fundamental lynchpin of Skype’s living-room strategy, and we are focused on enabling amazing new in-game and in-console voice and video experiences for the next generation of Xbox. This is a crucial initiative for Xbox, and it is time-critical given the hardware lead times involved.
This job listing strongly hints that games on the next Xbox would be able to launch Skype voice and video calls while playing, for example, the latest Call of Duty game. It's possible that Skype could even replace the current Xbox voice messaging system.
Skype support has already been added to one current game console, but it's not the Xbox 360. Sony added a Skype client to its new PS Vita portable game console in April, a couple of months after the console launched in the US. So far, Microsoft has not commented on when Skype support might be added to the Xbox 360.